Ketoconazole as a Possible Universal Inhibitor of Cytochrome P-450 Dependent Enzymes: Its Mode of Inhibition
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منابع مشابه
Cytochrome P-450 1A1 expression in human small bowel: interindividual variation and inhibition by ketoconazole.
Human cytochrome P-450 1A1 (CYP1A1) is located primarily in extrahepatic tissues. To begin the characterization of this enzyme in the small intestine, we screened a bank of 18 human small intestinal microsomal preparations for CYP1A1 catalytic [(7-ethoxyresorufin O-deethylase (EROD)] activity and protein content. Although EROD activity was below detectable limits in 12 of the preparations, 6 ex...
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Title 1 Function of cytochrome P450 enzymes RosC and RosD in the 2 biosynthesis of rosamicin macrolide antibiotic produced by 3 Micromonospora rosaria 4 5 Running Title 6 CYTOCHROME P450 RosC & RosD IN ROSAMICIN BIOSYNTHESIS 7 8 Yohei Iizaka, Noriko Higashi, Masanari Ishida, Reina Oiwa, Yumi Ichikawa, 9 Moeka Takeda, Yojiro Anzai*, and Fumio Kato 10 11 Faculty of Pharmaceutical Sciences, Toho U...
متن کاملReactions and significance of cytochrome P-450 enzymes.
Cytochrome P-450 enzymes (EC 1.14.14.1, nonspecific monooxygenase) catalyze the oxidations of many chemicals (1). The mass of the substrates ranges from that of ethylene (Mr 28) to that of cyclosporin A ( M , 1201). The classification of a hemoprotein as a P-450’ is defined by its absorption spectrum; the Fe(I1)CO complex has a characteristic absorption maximum (Soret band) near 450 nm due to a...
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The presence of a very active cytochrome P-450-dependent drug-metabolizing system in the olfactory epithelium has been confirmed by using 7-ethoxycoumarin, 7-ethoxyresorufin, hexobarbitone and aniline as substrates, and the reasons for the marked activity of the cytochrome P-450 in this tissue have been investigated. The spectral interaction of hexobarbitone and aniline with hepatic and olfacto...
متن کاملKetoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes.
Ketoconazole has recently been shown to interfere with steroidogenesis in patients and rat in vitro systems. In this study we attempted to elucidate the site of inhibition in the adrenal gland. Although ketoconazole impaired adrenocorticotropic hormone stimulated cyclic (c)AMP production, dibutyrl cAMP addition did not bypass the steroidogenic blockade indicating that the critical ketoconazole-...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1987
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.34.105